LC Determination of Entacapone in Tablets: In Vitro Dissolution Studies
نویسندگان
چکیده
منابع مشابه
Entacapone Tablets
Entacapone is an inhibitor of catechol O methyltransferase (COMT), used in the treatment of Parkinson’s Disease as an adjunct to levodopa and carbidopa therapy. It is a nitrocatechol structured compound with a relative molecular mass of 305.29. The chemical name of entacapone is (E) 2 cyano 3 (3,4 dihydroxy 5 nitrophenyl) N,N diethyl 2 propenamide. Its empirical formula is C H N O and its struc...
متن کاملLC determination of impurities in azithromycin tablets.
A LC method with UV detection for determining azithromycin impurities in tablets as pharmaceutical form has been developed. It is to be employed in routine and stability tests. A linear gradient elution was employed starting with 47% A and 53% B to reach 28% A and 72% B at 48 min. Mobile phase A was KH2PO4 10 mM (H2O) at pH 7.00. B was a mixture methanol:acetonitrile 1:1 (v/v). UV detection was...
متن کاملControlled-Release Low Density Effervescent Floating Matrix Tablets of Risperidone: Development, Optimization, in vitro-in vivo Evaluation in Healthy Human Volunteers and Determination of Dissolution Equivalency
The main objective of the present study was to formulate gastroretentive effervescent sustained release drug delivery systems of risperidone floating tablets with the help of Methocel® K15, Ethocel® standard 7FP premium, Eudragit ® RS100 sustained release polymers to improve its safety profile, bioavailability and patient compliance. Risperidone floating tablets were formulated by wet granulati...
متن کاملStability and In Vitro Dissolution Studies of Metronidazole Tablets and Infusions
The aim of this study was to compare metronidazole tablets (500 mg) and infusions (500 mg/100 mL) obtained from Saudi and Egyptian suppliers. Evaluation of the tablets included weight variation, hardness, friability, drug content, disintegration time, and dissolution profiles. Stability of the tablets in their original packages after 3-month storage at various temperatures (75% relative humidit...
متن کاملIn Vitro Release Studies of Enoxaparin in Nanoparticle form and Enterically Coated Tablets Containing Surfactants
In the past decade, many strategies have been developed to enhance oral drug delivery. Different techniques were investigated, amongst those the use of permeation enhancers such surfactants and biodegradable polymers were studied more extensively. Chitosan and its derivatives have been studied as permeation enhancer. The aim of the current study was to develop a nanoparticulate system based on ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Chromatographic Science
سال: 2010
ISSN: 0021-9665,1945-239X
DOI: 10.1093/chromsci/48.9.755